Status:
COMPLETED
Daily Sedative Interruption in Critically Ill Patients Being Managed With a Sedation Protocol
Lead Sponsor:
Mount Sinai Hospital, Canada
Collaborating Sponsors:
The Physicians' Services Incorporated Foundation
Conditions:
Critical Illness
Mechanical Ventilation
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
All critically ill, mechanically ventilated patients in the Intensive Care Unit receive medications to relieve pain and anxiety. However, accumulation of these medications can be associated with serio...
Eligibility Criteria
Inclusion
- age\>18 years
- Mechanically ventilated, with anticipated need for MV ≥ 48 hours
- ICU team has decided to initiate continuous sedative/analgesic infusion(s)
- informed consent.
Exclusion
- Admission after resuscitation from cardiac arrest
- Traumatic brain injury
- Currently receiving neuromuscular blocking agents
- Allergy to any of the study medications
- History of alcohol, sedative or analgesic abuse
- History of psychiatric illness
- Acute or chronic neurologic dysfunction
- Administration of sedatives for \>24 hr,
- Lack of commitment to aggressive treatment
- Current enrollment in a related trial
- Previous enrollment in this trial.
Key Trial Info
Start Date :
February 1 2001
Trial Type :
INTERVENTIONAL
End Date :
September 1 2004
Estimated Enrollment :
65 Patients enrolled
Trial Details
Trial ID
NCT00298493
Start Date
February 1 2001
End Date
September 1 2004
Last Update
March 2 2006
Active Locations (1)
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1
Mount Sinai Hospital
Toronto, Ontario, Canada, M5G 1X5