Status:
COMPLETED
Mycophenolate Mofetil (MMF) Versus Intravenous CTX Pulses in the Treatment of Adult Severe HSPN
Lead Sponsor:
Nanjing University School of Medicine
Conditions:
Henoch-Schoenlein Purpura
Nephritis
Eligibility:
All Genders
16-50 years
Phase:
NA
Brief Summary
This study is performed to compare the efficacy, safety, tolerability and relapse of MMF vs CTX in the treatment of severe HSPN
Detailed Description
Henoch-Schoenlein purpura nephritis (HSPN) with massive proteinuria,renal insufficiency and crescent formation at onset have high risks of progressing to end stage renal failure. Though clinical studi...
Eligibility Criteria
Inclusion
- 16-50 years
- Biopsy proved HSP
- Proteinuria ≥ 3.0 g/24hr
- Scr \< 5.0 mg/dl
Exclusion
- Cytotoxic drug treatment such as CTX, CsA, MMF for morn than 1 month-3 months prior to enrolled
- Pregnancy
- Active/serious infections
- Previous diagnosed diabetes mellitus type 1 or 2
Key Trial Info
Start Date :
January 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2006
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00301613
Start Date
January 1 2003
End Date
January 1 2006
Last Update
May 27 2010
Active Locations (1)
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1
Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine
Nanjing, Jiangsu, China, 210002