Status:
COMPLETED
Blood Pressure Lowering Effects of Grape Juice
Lead Sponsor:
Boston University
Collaborating Sponsors:
Welch's, Inc.
Conditions:
Hypertension
Eligibility:
All Genders
21-75 years
Phase:
NA
Brief Summary
Recent studies suggest that a diet rich in fruit and vegetables can lower blood pressure, and a number of lines of evidence suggest that grape products may have such an effect. The purpose of this stu...
Detailed Description
Elevated blood pressure (BP) is among the most common and important risk factors for atherosclerosis. A number of non-pharmacological therapies have successfully been applied to prevent the developmen...
Eligibility Criteria
Inclusion
- Adult males and females
- Body Mass Index (BMI) of less than 35.0 kg/m2
- Systolic blood pressure (130-159 mmHg) and/or diastolic blood pressure (85-99 mm Hg) on two screening visits
- Subject must be judged to be in good health on the basis of medical history; 5. Subject must not be taking any antihypertensive medications for at least one month prior to the Screening Visit
Exclusion
- History of clinically defined coronary artery disease, peripheral artery disease, stroke, active gastrointestinal ulcers, renal, or hepatic disease;
- History of bleeding disorders or malabsorption syndromes;
- Taking drugs for regulating hemostasis, including stable-dose aspirin;
- History of active cancer
- Females who are pregnant or planning to become pregnant
- Use of weight-loss drugs (including over-the-counter and dietary supplements)
- Diagnosed diabetes mellitus
- Subjects who consume a vegetarian diet
- Recent history (within the past 6 months) of alcohol or substance abuse.
- Laboratory values outside the following ranges: serum potassium (3.5-5.1 mg/dl), creatinine (0.5-1.3 mg/dl), hematocrit (36-50%), white blood count (4.0-11.0 K/ul), platelet count (150-400 k/ul)
Key Trial Info
Start Date :
March 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2009
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00302809
Start Date
March 1 2006
End Date
May 1 2009
Last Update
June 18 2009
Active Locations (1)
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1
Boston Medical Center
Boston, Massachusetts, United States, 02118