Status:
COMPLETED
Tolerability and Efficacy of High Dose Escitalopram for the Treatment of Obsessive-Compulsive Disorder (OCD)
Lead Sponsor:
Abarbanel Mental Health Center
Conditions:
Obsessive-Compulsive Disorder
Eligibility:
All Genders
18-75 years
Phase:
PHASE3
Brief Summary
Objectives: To evaluate tolerability and efficacy of escitalopram treatment in high dose than 20-50 mg/d in out-patients with OCD Type of the study: Open label, prospective study. Number of patients:...
Detailed Description
Objectives: To evaluate tolerability and efficacy of escitalopram treatment in doses higher than 20mg (20-50 mg/d) in patients with OCD, non responsive or partially responsive to recommended doses. T...
Eligibility Criteria
Inclusion
- Men and women over 18 years of age
- DSM IV-TR criteria for OCD
- OCD associated with most distress or most interference in the patient's life as judged by the treating physician
- Yale-Brown Obsessive Compulsive Scale (YBOCS) total score ≥ 16
Exclusion
- Other primary or co-primary psychiatric disorder which is more distressful for the patient then the OCD, as evaluated by investigator
- Patients with any history of mania/bipolar disorder
- Patients using medications which are contraindicated with the use of escitalopram
- Known contraindication for the use of citalopram or escitalopram.
- Unable to understand and give informed consent
- Prominent suicidal ideation (2 points or more in the MADRS "suicidal thoughts" item)
- Alcohol or substance dependence in the past 6 months
- Major physical illness
- Woman currently pregnant or less then 4 weeks after a childbirth, a woman lactating, or a woman of childbearing potential not using a medically accepted form of contraception.
- Liver function abnormality
- EKG abnormalities
Key Trial Info
Start Date :
March 1 2006
Trial Type :
INTERVENTIONAL
End Date :
December 1 2006
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00305500
Start Date
March 1 2006
End Date
December 1 2006
Last Update
July 26 2006
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Abarbanel MHC
Bat Yam, Israel, 59100