Status:
COMPLETED
Brain Imaging in Patients With Chronic Liver Disease and Functional Impairment.
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
Royal College of Physicians
Paddington Charitable Estates Educational Fund
Conditions:
Cirrhosis
Hepatic Encephalopathy
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Hepatic encephalopathy (HE) is a frequent complication of chronic liver disease (cirrhosis) and involves a wide spectrum of problems from mild impairment of reaction times in driving and operating mac...
Detailed Description
Hepatic encephalopathy (HE) is a common neuropsychiatric abnormality, complicating the course of liver disease patients. In the UK, cirrhosis accounts for 4000 deaths per year, and 500,000 people are ...
Eligibility Criteria
Inclusion
- Age 18-65
- Biopsy-proven cirrhosis
- Clinically stable
- Able to give informed consent
- Fluent English (required for psychometric testing)
Exclusion
- Ferro-magnetic implants
- Claustrophobia
- Weight \>120kg
- Significant renal impairment (Creatinine \>150 micromol/L)
- Poorly controlled Diabetes (particularly type I with microvascular complications)
- Alcohol: if alcoholic liver disease is the aetiology of their liver disease they should be abstinent. Otherwise less than 20g per day.
Key Trial Info
Start Date :
March 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2007
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00305591
Start Date
March 1 2006
End Date
October 1 2007
Last Update
May 29 2015
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Imperial College London
Hammersmith, London, United Kingdom, W12 0HS