Status:
UNKNOWN
Dopaminergic Enhancement of Learning and Memory in Healthy Adults and Patients With Dementia/Mild Cognitive Impairment
Lead Sponsor:
University Hospital Muenster
Conditions:
Alzheimer's Disease
Mild Cognitive Impairment
Eligibility:
All Genders
18-90 years
Phase:
PHASE4
Brief Summary
This study aims to determine whether levodopa is effective in boosting learning and memory in healthy subjects and patients with dementia or Mild Cognitive Impairment. We also examine in healthy subj...
Detailed Description
Prior work of our group shows that the dopamine precursor levodopa markedly improves word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind trial, we probe whe...
Eligibility Criteria
Inclusion
- Inclusion criteria for patients with dementia:
- Patients: clinical diagnosis of AD or mild cognitive impairment
- primary language German
- Exclusion Criteria for healthy subjects and patients with dementia/MCI:
- Known allergy to levodopa or tetrazine
- History of medication/drug abuse
- Acute nicotine withdrawal or \> 15 cigarettes per day
- \> 6 cups/glasses of coffee, caffeine drinks or energy drinks per day
- \> 50 grams of alcohol per day
- Severe hypertonia (systole \>160 mm Hg)
- Severe arteriosclerosis
- Diabetes, asthma, or glaucoma
- Severe hearing disability
- no focal brain lesions
- Premorbid depression or psychosis
- Medication with dopamine agonists or antagonists
- Parkinsonian symptoms
Exclusion
Key Trial Info
Start Date :
January 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2008
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00306124
Start Date
January 1 2006
End Date
March 1 2008
Last Update
October 25 2007
Active Locations (1)
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1
University of Muenster, Department of Neurology
Münster, North Rhine-Westphalia, Germany, 48129