Status:
UNKNOWN
The Prevalence of Vitamin D Deficiency and Effects of Vitamin D Supplementation in HIV-1 Infected Patients
Lead Sponsor:
Radboud University Medical Center
Conditions:
Vitamin D Deficiency
HIV Infections
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine the effect of normalization of vitamin D levels on bone density, immune and adipocyte function in HIV1-seropositive patients.
Detailed Description
Vitamin D deficiency is common in, especially black, HIV-seropositive patients. Vitamin D deficiency can be caused by lack of sunlight and/or insufficient vitamin D intake via diet. The HIV infection ...
Eligibility Criteria
Inclusion
- \>18 jr
- able to give informed consent
- HIV seropositive diagnosed with standard techniques
- Hypovitaminoses D
Exclusion
- Hypercalcemia: calcium levels \>2.60 mmol/L
- Renal disorders: serum creatinine \>2 times Upper limit of normal (ULN) (110 mmol/l)
- Liver disorders; elevation of ASAT or ALAT \>5 x ULN. The ULNs are 40 IU/L and 45 IU/L for ASAT and ALAT, respectively.
- Pregnancy
- Drug or alcohol abuse
- Non compliance
Key Trial Info
Start Date :
January 1 2006
Trial Type :
INTERVENTIONAL
End Date :
July 1 2007
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT00306410
Start Date
January 1 2006
End Date
July 1 2007
Last Update
March 1 2007
Active Locations (1)
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1
Radboud University Nijmegen Medical Center
Nijmegen, Netherlands, P.O. BOX 9101