Status:
COMPLETED
Does The Addition Of Divalproex Sodium ER To An Atypical Antipsychotic Drug (APD) Improve Cognition And Psychopathology In Outpatients With Schizophrenia (SCH) Or Schizoaffective Disorder (SAD)?
Lead Sponsor:
Northwestern University
Collaborating Sponsors:
National Alliance for Research on Schizophrenia and Depression
Abbott
Conditions:
Schizophrenia
Schizoaffective Disorder
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
The major objective of this proposal is to test the hypothesis that the addition of divalproex sodium to an atypical antipsychotic drug other than clozapine will significantly improve: a) cognition; a...
Detailed Description
Cognitive function is one of the most critical deficits in schizophrenia and schizoaffective disorder. It has been found that cognitive dysfunction may be even more important than positive or negative...
Eligibility Criteria
Inclusion
- Inclusion criteria
- Male or female, age 18-65
- Diagnostic and Statistical Manual (DSM-IV) diagnosis of schizophrenia or schizoaffective disorder
- Treated with olanzapine, aripiprazole, ziprasidone, quetiapine or risperidone monotherapy for at least three months prior to enrollment
- Able to provide written consent
- Exclusion criteria
- Primary DSM-IV diagnosis other than schizophrenia or schizoaffective disorder
- Treatment with any antipsychotic other than olanzapine, aripiprazole, ziprasidone, quetiapine or risperidone in the past three months
- Treatment with a mood stabilizer or an antidepressant continuously in the past three months. Patients who have had it for less than two weeks continuously will be permitted to enter.
- Pregnant or lactating females
Exclusion
Key Trial Info
Start Date :
March 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2008
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00306475
Start Date
March 1 2006
End Date
April 1 2008
Last Update
June 27 2025
Active Locations (1)
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1
Psychiatric Hospital at Vanderbilt
Nashville, Tennessee, United States, 37212