Status:
TERMINATED
Myocardial Regeneration and Angiogenesis in Myocardial Infarction With G-CSF and Intra-Coronary Stem Cell Infusion
Lead Sponsor:
Seoul National University Hospital
Conditions:
Myocardial Infarction
Eligibility:
All Genders
Up to 80 years
Phase:
PHASE2
Brief Summary
This trial was performed to evaluate the safety and the efficacy of G-CSF based stem cell therapy in patients with AMI. MAGIC Cell-1 trial enrolled patients with acute and old myocardial infarction, a...
Detailed Description
We compared intra-coronary infusion of the mobilized PBSCs with G-CSF (n=10) and mobilization alone with G-CSF (n=10) in patients with myocardial infarction in MAGIC Cell -1 trial and G-CSF alone (n=6...
Eligibility Criteria
Inclusion
- MAGIC Cell-1 trial enrolled patients with acute and old myocardial infarction
- MAGIC Cell-2 trial enrolled patients with acute myocardial infarction presented within 12 hours after onset of chest pain who underwent successful primary PCI.
Exclusion
- Persistent severe heart failure (above Killip class II or LVEF \< 25 %)
- Uncontrolled myocardial ischemia or ventricular tachycardia
- Culprit lesion of infarct related artery not feasible for PCI or unsuccessful PCI
- Age \> 75 years
- Malignancy
- Serious current infection or hematologic disease
- Life expectancy under one year.
Key Trial Info
Start Date :
March 1 2004
Trial Type :
INTERVENTIONAL
End Date :
February 1 2005
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00307879
Start Date
March 1 2004
End Date
February 1 2005
Last Update
March 28 2006
Active Locations (1)
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1
Seoul National University Hospital, Yon-Gon Dong, Chongno-Gu
Seoul, Seoul, South Korea, 110-744