Status:
COMPLETED
Neurophysiology of Task-Specificity of Focal Hand Dystonia
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Focal Dystonia
Eligibility:
All Genders
18-80 years
Brief Summary
This study will examine how the brain coordinates movement in patients with focal hand dystonia. Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or a...
Detailed Description
Objective Currently, there is no cure for focal hand dystonia (FHD). FHD research has focused predominantly on the motor execution abnormality in the primary motor cortex, while the task-specific nat...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Patients:
- Age over 18 years
- Presence of FHD, specifically writer's cramp
- Healthy volunteers:
- Age over 18 years
- Absence of dystonia or other neurologic condition
- EXCLUSION CRITERIA:
- Patients and Healthy volunteers:
- Concurrent medical, surgical, neurologic or psychiatric condition
- Taking medications which include antidepressants, anxiolytics, anticonvulsants, antipsychotics, antiparkinson, hypnotics, stimulants, and/or antihistamines
- Received botulinum toxin injection within 3 months of starting the protocol
- Presence of pacemaker, implanted medical pump, metal plate or metal object in skull or eye
- History of seizure disorder
- For healthy volunteers undergoing MRI, subjects with implanted devices such as pacemakers, medication pumps or defibrillators, metal in the cranium except mouth, intracardiac lines, history of shrapnel injury or any other condition/device that may be contraindicated or prevent the acquisition of MRI and/or current pregnancy
- A serious medical illness which prevents them from lying flat for up to 60 minutes
- Claustrophobia (a fear of tight spaces), which prevents them from lying still in a tight or small space for up to 60 minutes
Exclusion
Key Trial Info
Start Date :
March 28 2006
Trial Type :
OBSERVATIONAL
End Date :
February 24 2009
Estimated Enrollment :
115 Patients enrolled
Trial Details
Trial ID
NCT00309010
Start Date
March 28 2006
End Date
February 24 2009
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892