Status:
COMPLETED
Vitamin E to Prevent Mucositis in Children With Cancer
Lead Sponsor:
The Hospital for Sick Children
Conditions:
Cancer
Eligibility:
All Genders
6-18 years
Phase:
PHASE2
PHASE3
Brief Summary
The primary objective is to determine whether in children undergoing doxorubicin-containing chemotherapy, if topical vitamin E, when compared to placebo, decreases an objective measurement of oral muc...
Detailed Description
Oral mucositis is a common consequence of chemotherapy and is an important sequela of cancer therapy because it is painful and affects quality of life, may lead to hospitalization for hydration or pai...
Eligibility Criteria
Inclusion
- diagnosis of cancer and treated at the Hospital for Sick Children, Toronto, Canada
- planned chemotherapy includes at least two identical courses of doxorubicin-containing chemotherapy in which the dose of doxorubicin was at least 60 mg/m2 per course
- at least 6 years of age and less than 18 years
- lives in the Greater Toronto area
Exclusion
- allergy to vitamin E or placebo ingredients
- child is unable to comply with topical vitamin E application
- cild is receiving head or neck irradiation
Key Trial Info
Start Date :
July 1 2002
Trial Type :
INTERVENTIONAL
End Date :
February 1 2005
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00311116
Start Date
July 1 2002
End Date
February 1 2005
Last Update
December 18 2013
Active Locations (1)
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1
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8