Status:
COMPLETED
Effect of Yogurt on Minimal Hepatic Encephalopathy
Lead Sponsor:
Medical College of Wisconsin
Collaborating Sponsors:
National Center for Research Resources (NCRR)
Conditions:
Cirrhosis
Minimal Hepatic Encephalopathy
Eligibility:
All Genders
24-65 years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether a special yogurt can improve performance on certain tests of intelligence and decrease liver inflammation in patients with cirrhosis.
Detailed Description
Introduction: Cirrhosis is one of the leading causes of death in the United States. Minimal hepatic encephalopathy (MHE) is a significant complication of cirrhosis, which is often not treated because ...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Cirrhosis diagnosed on clinical grounds (within 3 months of enrollment)
- MHE diagnosed by abnormalities in a psychometric battery (NCT-A,BDT,DST and ICT)
- Exclusion criteria:
- Current or recent (\< 6 month) use of alcohol
- Co-existing cause of liver dysfunction
- Use of antibiotics within last 6 weeks
- Infection or gastrointestinal hemorrhage within the last 6 weeks
- Hepatocellular carcinoma
- Psychoactive drug use, including interferon concurrently
Exclusion
Key Trial Info
Start Date :
November 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2007
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00312078
Start Date
November 1 2005
End Date
April 1 2007
Last Update
November 1 2007
Active Locations (1)
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1
GCRC Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226