Status:
COMPLETED
Aminophylline in Bradyasystolic Cardiac Arrest
Lead Sponsor:
Vancouver General Hospital
Collaborating Sponsors:
Heart and Stroke Foundation of Canada
Vancouver Coastal Health Research Institute
Conditions:
Cardiac Arrest
Eligibility:
All Genders
16+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to evaluate the effect of aminophylline in patients with out-of-hospital bradyasystolic cardiac arrest.
Detailed Description
Out-of-hospital cardiac arrest treated by emergency medical services has an estimated incidence of 54.99 per 100,000 person years, which translates to some 155,000 episodes annually in the United Stat...
Eligibility Criteria
Inclusion
- Cardiac arrest
- Bradyasystole either as the presenting rhythm or as a rhythm developing during the course of the resuscitation
- Endotracheally intubated and ventilated with 100% oxygen
- Intravenous (IV) access established
- Bradyasystolic without palpable pulses after 1 mg of epinephrine and 3 mg of atropine.
Exclusion
- A do-not-resuscitate directive
- Pregnancy
- Evidence of hemorrhage, trauma or hypothermia as a cause of the cardiac arrest
- Renal dialysis
- Theophylline hypersensitivity
- Patients taking an oral theophylline product
- Resuscitations directed by a paramedic student under practicum supervision
Key Trial Info
Start Date :
January 1 2001
Trial Type :
INTERVENTIONAL
End Date :
July 1 2004
Estimated Enrollment :
966 Patients enrolled
Trial Details
Trial ID
NCT00312273
Start Date
January 1 2001
End Date
July 1 2004
Last Update
July 27 2006
Active Locations (1)
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1
Vancouver General Hospital
Vancouver, British Columbia, Canada, V5Z 1M9