Status:
COMPLETED
Effects of Topical Clonidine vs. Brimonidine on Choroidal Blood Flow and Intraocular Pressure During Isometric Exercise
Lead Sponsor:
Medical University of Vienna
Conditions:
Ocular Physiology
Regional Blood Flow
Eligibility:
MALE
19-35 years
Phase:
PHASE4
Brief Summary
Brimonidine tartrate is an alpha-2 agonist ocular hypotensive drug that exerts its effect by causing both a decrease in aqueous production and an increase in uveoscleral outflow. It has been proven to...
Eligibility Criteria
Inclusion
- Men aged between 19 and 35 years, nonsmokers
- Body mass index between 15th and 85th percentile (Must A et al. 1991)
- Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
- Normal ophthalmic findings, ametropy \< 3 Dpt.
- Intraocular pressure between 10 and 18 mmHg.
Exclusion
- Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study
- Treatment in the previous 3 weeks with any drug
- Symptoms of a clinically relevant illness in the 3 weeks before the first study day
- History of hypersensitivity to the trial drug or to drugs with a similar chemical structure
- History or presence of gastrointestinal, liver or kidney disease, or other conditions known to interfere with, distribution, metabolism or excretion of study drugs
- Blood donation during the previous 3 weeks
- History or family history of epilepsy
Key Trial Info
Start Date :
February 1 2004
Trial Type :
INTERVENTIONAL
End Date :
December 1 2004
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT00312416
Start Date
February 1 2004
End Date
December 1 2004
Last Update
February 12 2007
Active Locations (1)
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1
Department of Clinical Pharmacology
Vienna, Austria, 1090