Status:
COMPLETED
Probiotics for the Prevention of Major Complications of Cirrhosis
Lead Sponsor:
Meir Medical Center
Collaborating Sponsors:
Ambrosia - SupHerb Ltd.
Conditions:
Liver Cirrhosis
Eligibility:
All Genders
Phase:
NA
Brief Summary
The purpose of this study is to determine whether probiotics are effective in the prevention of the complications of liver cirrhosis.
Detailed Description
Colonic bacteria clearly play a major role in the pathogenesis of major complications in patients with liver cirrhosis. By producing ammonia and endotoxins they can cause hepatic encephalopathy , and ...
Eligibility Criteria
Inclusion
- Patients with liver cirrhosis with at least one of the followings
- 1)Major complication of cirrhosis in the past (including variceal bleeding, encephalopathy and SBP) 2)Evidence for portal hypertension 3)Reduced hepatic synthetic function
- \-
Exclusion
- Patients with alcoholic cirrhosis who still consume alcohol
- Patients that are chronically treated with antibiotics or lactulose -
Key Trial Info
Start Date :
April 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2007
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00312910
Start Date
April 1 2005
End Date
October 1 2007
Last Update
May 22 2008
Active Locations (1)
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1
Meir Medical Center
Kfar Saba, Israel