Status:
COMPLETED
Concentrations of Amiodarone in Fat Tissue During Chronic Treatment
Lead Sponsor:
Hopital Lariboisière
Collaborating Sponsors:
Unité de Recherches Therapeutiques - H. Lariboisiere
Conditions:
Arrhythmia
Atrial Fibrillation
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The objective of this study is to determine if concentrations of amiodarone in fat tissue increases constantly over time during chronic treatment with this drug, and if blood concentrations reflect ac...
Detailed Description
Amiodarone is very effective to treat cardiac arrhythmias but its use is limited by its toxicity, specially in chronic treatment. Accumulation of the drug in tissues is very probably the cause of the ...
Eligibility Criteria
Inclusion
- Adult patients taking amiodarone for more than 3 months (any dose, any indication)
Exclusion
- Impossibility to perform needle aspiration of abdominal wall (local infection, skin disease)
- Coagulation disorders, INR \> 3.0 if warfarin treatment
- Patient unable to give informed consent
Key Trial Info
Start Date :
April 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2007
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00313443
Start Date
April 1 2006
End Date
October 1 2007
Last Update
July 14 2011
Active Locations (1)
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1
Hopital Lariboisiere, Internal Medicine "A" and Cardiology Services
Paris, France, 75010