Status:
UNKNOWN
Cooperative Huntington's Observational Research Trial
Lead Sponsor:
HP Therapeutics Foundation
Collaborating Sponsors:
Huntington Study Group
Conditions:
Huntington Disease
Eligibility:
All Genders
Brief Summary
The purpose of this study is to collect prospective data from individuals who are part of a Huntington Disease (HD) family, in order to relate phenotypes between individuals and families with each oth...
Detailed Description
COHORT (Cooperative Huntington Observational Research Trial) is a coordinated research effort by Huntington Study Group research centers worldwide to prospectively collect data from consenting individ...
Eligibility Criteria
Inclusion
- (1) MANIFEST/PRE-MANIFEST HD: Individuals of any age who are affected by HD OR an individual 18 years or older who - has tested positive for the HD gene.
- (2) INDIVIDUALS AT RISK: An individual 18 years or older who has not undergone DNA testing for the mutation responsible for HD and who is a first degree relative (parent, sibling, child) of an individual with Manifest or pre-manifest HD OR an older adolescent 15 to 17 years of age who has a parent with manifest HD or pre-manifest HD enrolled in COHORT.
- (3) ADULTS AT SECONDARY RISK: An individual 18 years of age or older who has not undergone DNA testing for the mutation responsible for HD and is a grandparent or grandchild of an individual enrolled in COHORT who has manifest HD or pre-manifest HD
- (4) CONTROL: A spouse or caregiver, 18 years of age or older, of an individual enrolled in COHORT who has manifest HD or pre-manifest HD
- (5) ADULT GENE NEGATIVE: An individual, 18 years of age or older, with a family history of HD who has undergone DNA testing and does not carry the genetic mutation responsible for HD.
Exclusion
- (1) Anyone who does not fit the inclusion criteria
Key Trial Info
Start Date :
February 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2020
Estimated Enrollment :
5000 Patients enrolled
Trial Details
Trial ID
NCT00313495
Start Date
February 1 2006
End Date
December 1 2020
Last Update
March 7 2011
Active Locations (52)
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1
University of Alabama at Birmingham
Birmingham, Alabama, United States
2
UCLA School of Medicine
Los Angeles, California, United States
3
University of California, Davis
Sacramento, California, United States
4
University of California, San Diego
San Diego, California, United States