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Status:

UNKNOWN

Combination Chemotherapy Followed By Stem Cell Transplant in Treating Young Patients With Progressive or Relapsed Anaplastic Large Cell Lymphoma

Lead Sponsor:

European Inter-group Cooperation on Childhood and Adolescent Non Hodgkin Lymphoma

Conditions:

Lymphoma

Eligibility:

All Genders

Up to 21 years

Phase:

NA

Brief Summary

RATIONALE: Giving combination chemotherapy and total-body irradiation before a peripheral stem cell transplant that uses the patient's or a donor's stem cells, helps stop both the growth of cancer cel...

Detailed Description

OBJECTIVES: Primary * Improve the probability of event-free survival in children and adolescents with early progression of anaplastic large cell lymphoma (ALCL) and/or relapse of ALCL with CD3-posit...

Eligibility Criteria

Inclusion

  • DISEASE CHARACTERISTICS:
  • Histologically or cytologically confirmed anaplastic large cell lymphoma (ALCL)
  • Progressive disease OR first relapse
  • No second or subsequent relapse of ALCL
  • Slides available for national central pathology review
  • Availability of 1 of the following (for allogeneic stem cell transplantation only):
  • HLA-identical matched sibling donor
  • 10/10 HLA-matched nonsibling donor (related or unrelated)
  • 9/10 HLA-matched nonsibling donor (1-antigen-mismatched related or unrelated donor)
  • \< 9/10 HLA-mismatched donor (related or unrelated)
  • Stem cells may be obtained from unmanipulated bone marrow or peripheral blood stem cells after filgrastim (G-CSF) stimulation
  • PATIENT CHARACTERISTICS:
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception
  • Adequate hepatic, renal, and cardiac function
  • No HIV infection or AIDS
  • No severe immunodeficiency
  • No other prior malignancy
  • No pre-existing disease or condition prohibiting study treatment
  • PRIOR CONCURRENT THERAPY:
  • At least 2 months since prior chemotherapy or radiotherapy
  • No significant pretreatment for first relapse
  • No prior organ transplantation
  • No concurrent participation in another clinical trial

Exclusion

    Key Trial Info

    Start Date :

    April 1 2004

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ESTIMATED

    End Date :

    Estimated Enrollment :

    96 Patients enrolled

    Trial Details

    Trial ID

    NCT00317408

    Start Date

    April 1 2004

    Last Update

    September 25 2015

    Active Locations (98)

    Enter a location and click search to find clinical trials sorted by distance.

    Page 1 of 25 (98 locations)

    1

    St. Anna Children's Hospital

    Vienna, Austria, A-1090

    2

    U.Z. Gasthuisberg

    Leuven, Belgium, B-3000

    3

    University Hospital Brno

    Brno, Czechia, CZ-662 63

    4

    Charles University Hospital

    Prague, Czechia, CZ-150 06