Status:
TERMINATED
Enteral Glutamine in Critical Illness
Lead Sponsor:
Christiana Care Health Services
Conditions:
Critical Illness
Sepsis
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
Glutamine is an amino acid which is rapidly depleted in critical illness. It is used as energy by cells that line the gut, vital for immune system function, and works as an anti-oxidant. Glutamine sup...
Detailed Description
Glutamine, a nonessential amino acid, is preferred fuel for rapidly proliferating cells in human body. Those cells include the enterocytes in small intestine, lymphocytes, macrophages, and fibroblasts...
Eligibility Criteria
Inclusion
- Admission to MICU/ CICU
- Age greater than or equal to 18 years old
- Requirement for enteral nutrition
- Presence or planned insertion of central venous catheter as part of routine medical care
- Requirement for mechanical ventilation
- APACHE II Score \>/= 15
Exclusion
- Female of child-bearing age (i.e. less than 45 years old)
- Enteral nutrition begun prior to randomization
- Receiving Total Parenteral Nutrition
- Requirement for protein restriction
- Creatinine \>4 mg/dl
- History of cirrhosis and/or clinical signs of heptic encephalopathy
Key Trial Info
Start Date :
May 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2007
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00318331
Start Date
May 1 2006
End Date
September 1 2007
Last Update
March 13 2008
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Christiana Hospital
Newark, Delaware, United States, 19713