Status:
UNKNOWN
Effects of Age and Exercise on Blood Pressure Regulation
Lead Sponsor:
National Institute on Aging (NIA)
Conditions:
Cardiovascular Disease
Aging
Eligibility:
All Genders
55-75 years
Brief Summary
The purpose of this study is to investigate the effects of age, exercise and cardiovascular disease on blood pressure.
Detailed Description
This study is being done to find out how age, activity level, and the presence of heart disease affect the way the body controls blood pressure. A total of 80 individuals will be recruited for the stu...
Eligibility Criteria
Inclusion
- Sedentary Older Individuals Group:
- Healthy men and women ages 55-75
- Normally physically active (performing regular aerobic exercise less than 60 minutes per week) with aerobic capacities below the 80th percentile for age and gender
- Coronary Artery Disease (CAD) Group:
- Men and women ages 55-75
- Written authorization from participant's cardiologist to participate in the study (Note: if Dr. Zervos is the participant's cardiologist, their primary care physician will also be asked to give written authorization)
- Documented CAD by previous MI or angiography
Exclusion
- General exclusion criteria for all groups:
- Neurological diseases
- Diabetes
- History of migraine headaches
- Hypertension
- Glaucoma
- Pacemaker
- History of stroke or TIA
- High cholesterol
- Current cancer
- Benign prostatic hyperplasia
- Allergy to sulfa
- Carotid disease
- Currently taking anti-depression, anti-psychotic, or anti-anxiety medications
- Sedentary Older Individuals Group:
- Coronary artery or carotid vascular disease
- Coronary Artery Disease (CAD) Group:
- Myocardial Infarction (MI), Percutaneous Transluminal Coronary Angioplasty (PTCA) or Coronary Artery Bypass Graft (CABG) in the last 3 months
- Unstable angina, EF branch block severe valvular disease, chronic atrial fibrillation, and frequent atrial or ventricular arrhythmias (including more than 3 PVCs or APCs per minute)
- Currently taking anticoagulants or any cardioactive medications other than ACE inhibitors, calcium channel blockers, and beta-blockers
Key Trial Info
Start Date :
April 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2007
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00319397
Start Date
April 1 2004
End Date
March 1 2007
Last Update
December 14 2009
Active Locations (1)
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1
Spaulding Rehabilitation Hospital
Boston, Massachusetts, United States, 02114