Status:
COMPLETED
Serotonin Transporter Concentrations in Women With a History of Anorexia Nervosa
Lead Sponsor:
New York State Psychiatric Institute
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Eating Disorders
Anorexia Nervosa
Eligibility:
FEMALE
18-45 years
Brief Summary
This study will compare the concentrations of serotonin transporter in the brains of women with a history of anorexia nervosa who are currently maintaining a normal weight to those of healthy women of...
Detailed Description
Anorexia nervosa (AN) is a serious eating disorder that is associated with substantial morbidity and mortality. Despite being dangerously underweight, people with AN believe that they are overweight, ...
Eligibility Criteria
Inclusion
- History of anorexia nervosa
- BMI has been greater than 18.5 kg/m² for at least 9 months
- Agrees to use an effective method of contraception
- Off all psychotropic and other types of medications likely to impact the serotonin system for at least 21 days
Exclusion
- Use of any psychotropic medication or other types of medications that are likely to affect the serotonin system within 21 days of study entry
- Current DSM-IV Axis-I diagnosis of any illness other than an eating disorder
- Current AN or history of AN within 9 months prior to study entry
- Presence of any psychiatric symptom that would make participation unsafe
- Significant active physical illnesses, particularly those that may affect the brain or serotonergic system, including the following: blood dyscrasias lymphomas; hypersplenism; endocrinopathies; renal failure or chronic obstructive lung disease; autonomic neuropathies; low hemoglobin; anemia; peripheral vascular disease; and malignancy
- Currently receiving effective medication treatment for an eating disorder
- History of Raynaud's phenomena and/or acrocyanosis
- Significant regular tobacco use (defined as more than 1 pack per week)
- Lacks capacity to consent
- Pregnant
- Breastfeeding
- Any metal implants, pacemaker, metal prostheses, orthodontic appliances, or the presence of shrapnel
- Significant history of claustrophobia that would complicate the completion of MRI
- Current or past radiation exposure in the workplace or as part of a research protocol in the previous year
- Badged for radiation
- Inclusion for Healthy Controls:
- Female age 18-45
- BMI \>18.5 kg/m
- Drug and medication free
- Willingness to engage in effective birth controls
- Exclusion for Healthy Controls
- History of any DSM-IV Axis - I diagnosis
- History of Axis II disorder that would be accompanied by impulse control problems or significant suicidal behavior
- Significant active physical illness
- Lacks capacity to consent
- Pregnancy, currently lactating
- Metal implants, pacemaker or metal prostheses or orthodontic appliances or shrapnel
- Current, past radiation exposure in the workplace or as part of a research protocol in the previous year or badged for radiation
Key Trial Info
Start Date :
July 1 2003
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2009
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00320684
Start Date
July 1 2003
End Date
June 1 2009
Last Update
July 2 2012
Active Locations (1)
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1
New York State Psychiatric Institute
New York, New York, United States, 10032