Status:
UNKNOWN
Pharmacogenomics of Anti-TNF (Anti-tumor Necrosis Factor) Treatment in Patients With Rheumatoid Arthritis
Lead Sponsor:
Radboud University Medical Center
Conditions:
Rheumatoid Arthritis
Eligibility:
All Genders
18+ years
Brief Summary
The main aim of this study is to identify genetic markers (at DNA and RNA level) which are involved in the response to treatment with monoclonal antibodies against TNF in patients with rheumatoid arth...
Detailed Description
Rheumatoid Arthritis (RA) is a severe inflammatory disease and genetic factors are known to play an important role in its pathogenesis. Genetic factors are also involved in determining the prognosis o...
Eligibility Criteria
Inclusion
- Patients with RA according to the ACR criteria who are treated with monoclonal anti-TNF antibodies.
Exclusion
Key Trial Info
Start Date :
May 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2014
Estimated Enrollment :
700 Patients enrolled
Trial Details
Trial ID
NCT00321217
Start Date
May 1 2004
End Date
April 1 2014
Last Update
August 16 2012
Active Locations (3)
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1
Rijnstate
Arnhem, Netherlands, 6800 TA
2
Radboud University Nijmegen Medical Centre
Nijmegen, Netherlands, 6500 HB
3
St Maartenskliniek
Nijmegen, Netherlands, 6522 JV