Status:
COMPLETED
Magnetic Resonance Imaging to Detect Brain Damage in Patients With Multiple Sclerosis
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18-65 years
Brief Summary
This study will evaluate the ability of magnetic resonance imaging (MRI) using different magnet strengths (1.5, 3 and 7 Tesla) to detect damage in different parts of the brain in patients with multipl...
Detailed Description
OBJECTIVE: Among the factors contributing to the poor identification of grey and white matter pathology of multiple sclerosis (MS) patients, the low signal-to-noise ratio and consequential poor resolu...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Diagnosis of MS.
- Age between 18 and 65.
- Central nervous system white matter and grey matter focal disease which may mimic MS in its imaging appearance.
- EXCLUSION CRITERIA:
- Pregnancy or breastfeeding, since contrast is harmful in people who are breastfeeding.
- Unable to provide informed consent.
- Permanent tattooed makeup (eyeliner, lip, etc) or general tattoos.
- Any non-organic implant or any other device such as: cardiac pacemaker, insulin infusion pump, implanted drug infusion device, cochlear, otologic, or ear implant, transdermal medication patch (Nitro), any metallic implants or objects, body piercing(s), bone/joint pin, screw, nail, plate, wire sutures or surgical staples, shunt.
- Cerebral aneurysms clips, shrapnel or other metal imbedded in the body (such as from war wounds or accidents).
- Previous work in metal fields or with machines that may have left any metallic fragments in or near the eyes.
- Severe auto accidents in the past with non-certainty that a metal object is still present in the subject's body.
- Any psychological contraindications for MRI (e.g., suffering from claustrophobia).
- HEALTHY VOLUNTEERS INCLUSION CRITERIA:
- 1\. Age between 18 and 65
- HEALTHY VOLUNTEERS EXCLUSION CRITERIA:
- 1\. Same as for patients.
Exclusion
Key Trial Info
Start Date :
May 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 19 2011
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00321568
Start Date
May 1 2006
End Date
April 19 2011
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892