Status:
COMPLETED
Validation of Serum Creatinine Dosage and Renal Clearance
Lead Sponsor:
University Hospital, Ghent
Conditions:
Kidney Failure
Eligibility:
All Genders
18-60 years
Phase:
PHASE1
Brief Summary
This study has an open study design. The GFR will be measured using the renal clearance of inulin (Inutest) in volunteers with different stage of renal disease or without renal disease. A blood sample...
Detailed Description
In this study we will investigate the correlation between the GFR as measured by inulin clearance (golden standard) and the estimated GFR as measured by laboratories which used different serum creatin...
Eligibility Criteria
Inclusion
- Normal weight as defined by a Body Mass Index of 18 to 30 kg/m2.
- Subject is competent and willing to sign informed consent form after being given all the detailed information about the study. Informed consent form signed voluntarily.
- The subjects must be in stable clinical condition, with stable serum creatinin at least for 6 months.
- Persons with different stage of chronic renal disease and without kidney disease (living donors) who need an evaluation of the GFR or Admitted volunteers who easily obtain urine samples.
Exclusion
- Transplant patients
- Medication that will influence the serumcreatinine.
- Morbid obesity
- Pregnant, lactating females or females with childbearing potential without adequate contraception (use of oral contraceptives, IUD or condoms with spermicide).
- History of allergy or hypersensitivity to inulin
- Donation of blood in the 60 days preceding the first visit.
- Liver disease, heart failure, nephrotic syndrome.
- Patients in critically ill conditions.
- Malnutrition
- Postrenal kidney failure
Key Trial Info
Start Date :
May 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2010
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00323128
Start Date
May 1 2006
End Date
December 1 2010
Last Update
June 2 2011
Active Locations (2)
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1
Algemeen Stedelijk Ziekenhuis Aalst
Aalst, Belgium
2
University Hospital Ghent
Ghent, Belgium, 9000