Status:
COMPLETED
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing
Lead Sponsor:
Children's Mercy Hospital Kansas City
Conditions:
Growth Hormone Deficiency
Eligibility:
All Genders
5-40 years
Phase:
NA
Brief Summary
Specific Aim 1 Healthy male and female subjects and growth hormone (GH) deficient subjects display sexually dimorphic GH responses to GHRH administration Specific Aim 2 GH responses to GHRH in both h...
Detailed Description
Growth hormone deficiency affects disproportionately more males than females. Although ascertainment bias plays a role in this sexual dimorphism, no plausible mechanism to fully explain this differenc...
Eligibility Criteria
Inclusion
- Healthy subjects
- Males and females, Tanner stage V aged 15-40 years of age with no known endocrine problems
- Males and females, Tanner stage I, aged 5-8 years with no known endocrine problems
- GH subjects - Males and females, Tanner stage V, aged 15-21 years with a history of childhood growth hormone deficiency
Exclusion
- Healthy subjects
- History of GH deficiency or treatment or other known endocrine disorder
- Current height or adult height \<5th %
- Female subjects using hormonal methods of birth control
- Female subjects with irregular menstrual cycles
- GH subjects
- \- Subjects with GH deficiency who have not discontinued GH treatment for at least 2 months
Key Trial Info
Start Date :
July 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2009
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00324064
Start Date
July 1 2007
End Date
July 1 2009
Last Update
March 5 2010
Active Locations (1)
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1
Children's Mercy Hospital
Kansas City, Missouri, United States, 64108