Status:
COMPLETED
Molecular Quantification of Insulin mRNA
Lead Sponsor:
Children's Mercy Hospital Kansas City
Conditions:
Type 1 Diabetes Mellitus
Eligibility:
All Genders
1-17 years
Brief Summary
The objectives of this study are to: 1. quantitate the level of insulin mRNA in the while cell fraction of whole blood in selected groups of subjects, 2. determine the gene expression of markers of w...
Detailed Description
Indicators of active immune or chemically mediated beta cell destruction would be helpful for predicting the development and severity of autoimmune diabetes and monitoring the success of islet transpl...
Eligibility Criteria
Inclusion
- Male or female subjects ages 1 to 17 years of age
- Subjects with evidence of beta cell dysfunction or evidence of beta cell autoimmunity
- Subjects with new onset type 1 diabetes
- Non-diabetic and autoantibody negative siblings of subjects with new onset type 1 diabetes
- Unrelated nondiabetic controls with no family history of type 1 diabetes
- Of sufficient size to donate 10ml of blood
Exclusion
- None if subjects meet above inclusion criteria
Key Trial Info
Start Date :
February 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2009
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT00324207
Start Date
February 1 2006
End Date
January 1 2009
Last Update
March 5 2010
Active Locations (1)
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1
Children's Mercy Hospital
Kansas City, Missouri, United States, 64108