Status:
COMPLETED
Immune Responses to Smallpox Vaccination
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Smallpox Vaccine
Eligibility:
All Genders
18+ years
Brief Summary
This study will examine how people s immune systems respond to inoculation with vaccinia virus the standard vaccine used to protect against smallpox and how these responses correlate with symptoms the...
Detailed Description
Vaccinia virus is used to vaccinate persons to prevent disease with smallpox. Limited information is available regarding cellular immune responses to vaccinia virus. We will obtain blood from vaccinat...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- 18 years of age or older
- Both males and females
- Patients will be checked on day 0 and those with a hemoglobin of greater than or equal to12 g/dL will have blood drawn as described in the protocol. Patients with a hemoglobin of 11-11.9 will have a 50% reduction in the amount of blood drawn after the first visit from 40 ml per visit to 20 ml per visit. Patients with a hemoglobin less than 11 g/dL will be terminated from the study and referred for medical follow-up.
- Able to sign the consent form and be willing to comply with study procedures.
- Must be a laboratory worker, health care worker, or emergency response worker who is receiving smallpox vaccination as a routine part of employment. Persons who were previously vaccinated at least 8 months ago are eligible.
- EXCLUSION CRITERIA:
- Active substance abuse or history of prior substance abuse that may interfere with protocol compliance or compromise patient safety.
Exclusion
Key Trial Info
Start Date :
February 4 2003
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 15 2016
Estimated Enrollment :
69 Patients enrolled
Trial Details
Trial ID
NCT00325975
Start Date
February 4 2003
End Date
March 15 2016
Last Update
December 17 2019
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892