Status:
COMPLETED
A Phase I Dose-Escalation Study of BMS-641988 in Patients With Castration-Resistant Prostate Cancer
Lead Sponsor:
Bristol-Myers Squibb
Conditions:
Prostate Cancer
Eligibility:
MALE
18+ years
Phase:
PHASE1
Brief Summary
This is a Phase I Dose-Escalation Study of BMS641988 in Patients with Castration-Resistant Prostate Cancer.
Eligibility Criteria
Inclusion
- Advanced castration-resistant prostate carcinoma with progressive disease
- At least 4 weeks must have elapsed from major surgery
- Patient must be available for follow-up
- Adequate liver and kidney function
- Adequate blood values
Exclusion
- Uncontrolled or significant heart disease
- History of seizures
- History of head injury, loss of consciousness, or stroke
- Patients undergoing alcohol withdrawal
- Any concurrent cancer
- A serious uncontrolled medical disorder or active infection
- Inability to swallow tablets
Key Trial Info
Start Date :
May 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2009
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT00326586
Start Date
May 1 2006
End Date
March 1 2009
Last Update
January 25 2011
Active Locations (3)
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1
Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins
Baltimore, Maryland, United States, 21231
2
Memorial Sloan-Kettering Cancer Center
New York, New York, United States, 10021
3
University Of Wisconsin Hospital And Clinics Laboratory
Madison, Wisconsin, United States, 53792