Status:
COMPLETED
Primary Prevention of Major Depression in Later Life
Lead Sponsor:
University of Maryland, College Park
Collaborating Sponsors:
University of Pittsburgh
Conditions:
Depression
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
The Institute of Medicine has called for studies of "indicated" preventive interventions to reduce the incidence of mental illness in persons already symptomatic but not yet presenting with fully deve...
Detailed Description
306 participants will be randomly assigned to either problem solving therapy or to a dietary education control. PST will consist of 6 to 8 sessions, distributed over 6 to 16 weeks, teaching participan...
Eligibility Criteria
Inclusion
- Age 50 or greater
- Center for Epidemiological Studies of Depression Scale (CES-D) score of 11 or higher
- Folstein Mini-Mental State score of 24 or higher
- Not currently receiving antidepressant medication or participating in other mental health treatment
Exclusion
- Episode of major depression within the past 12 months
- Episode of alcohol or other substance abuse within the past 12 months
- Life time history of bipolar disorder or other psychotic disorder
- Diagnosis of any neurodegenerative disorder or of dementia (Alzheimer's, vascular, or frontotemporal dementia, etc.)
Key Trial Info
Start Date :
May 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
306 Patients enrolled
Trial Details
Trial ID
NCT00326677
Start Date
May 1 2006
End Date
December 1 2013
Last Update
January 15 2025
Active Locations (2)
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1
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213
2
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213