Status:
COMPLETED
Osteoporosis in Children With ALL
Lead Sponsor:
Children's Mercy Hospital Kansas City
Conditions:
Leukemia, Lymphocytic, Acute, L1
Eligibility:
All Genders
4-18 years
Brief Summary
Hypothesis: Pediatric patients with acute lymphoblastic leukemia, treated with chronic glucocorticoids as a part of the leukemia treatment protocol, will have an increased incidence and severity of o...
Detailed Description
Osteoporosis is a disease characterized by low bone mass and microarchitectural deterioration of bone tissue. Osteoporosis is a devastating disorder with significant physical, psychosocial and financi...
Eligibility Criteria
Inclusion
- All pediatric patients with a new diagnosis of ALL between ages 4-18
- Patients who are expected to receive glucocorticoids as part of the leukemia treatment protocol
- Bone density measurements must be performed at the diagnosis visit or maximally within 48 hours after the first dose of glucocorticoids
Exclusion
- Patients under 4 years of age are excluded due to lack of age appropriate standards for bone mineral density
- Glucocorticoid therapy of at least one month or longer within the six months prior to DX
- History of connective tissue or musculoskeletal disorders
- Biphosphonate therapy within the past 6 months
- Acute renal failure
- Serum creatinine equal to or higher than 4.5mg/dl
- Positive serum pregnancy test in adolescent females
Key Trial Info
Start Date :
March 1 2004
Trial Type :
OBSERVATIONAL
End Date :
October 1 2006
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00330538
Start Date
March 1 2004
End Date
October 1 2006
Last Update
April 6 2007
Active Locations (1)
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1
Children's Mercy Hospital
Kansas City, Missouri, United States, 64108