Status:
UNKNOWN
Serial Exhaled Breath pH Monitoring
Lead Sponsor:
University of Virginia
Conditions:
Gastroesophageal Reflux
Eligibility:
All Genders
5+ years
Brief Summary
This study will seek to determine the amount of acids a person with a chronic cough that is suspected to be related to acid reflux breathes out after coughing. The study will also seek to determine if...
Detailed Description
Acid reflux has been considered to be a key contributor to cough, particularly in patients with obstructive lung diseases. However, diagnosis has relied upon either responsiveness to high dose twice d...
Eligibility Criteria
Inclusion
- Outpatient
- 5 years of age and older
- Cough lasting a minimum of 3 weeks
- Has been prescribed a proton pump inhibitor as a single therapeutic and diagnostic effort to control the cough
Exclusion
- Inability to perform serial exhaled breath condensate collections at home
- Unwillingness to initiate proton pump inhibitor therapy as prescribed by physician
- Other changes planned in therapy, such as initiating or discontinuing cough suppressant therapy, initiating or augmenting antibiotic therapy, initiating or augmenting anti-inflammatory therapy
- Previous treatment of respiratory symptoms with proton pump inhibitor therapy
- Current treatment with angiotensin converting enzyme inhibitor medication or H2 antagonists
- Regular exposure to an environmental irritant
Key Trial Info
Start Date :
April 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2011
Estimated Enrollment :
99 Patients enrolled
Trial Details
Trial ID
NCT00330603
Start Date
April 1 2006
End Date
December 1 2011
Last Update
March 8 2011
Active Locations (1)
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1
University of Virginia
Charlottesville, Virginia, United States, 22908