Status:
COMPLETED
Improving Hand Movement Training Through Electrical Stimulation of the Brain
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Metaplasticity
Eligibility:
All Genders
18-50 years
Brief Summary
This study will determine if applying electrical stimulation of the brain can influence training to perform finger movements. The study may provide information that can be used to design rehabilitatio...
Detailed Description
OBJECTIVES: Training leads to performance improvements and motor learning. Cortical plasticity associated with training (use-dependent plasticity, UDP) contributes to performance improvements after b...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- age between 18-50 years
- able to perform tasks required by the study
- willing and able to give consent
- willing to make an eight-week commitment to the study
- possibility of obtaining TMS-evoked thumb movements in a consistent direction at baseline
- EXCLUSION CRITERIA:
- unable to perform the tasks
- history of severe alcohol or drug abuse, psychiatric illness such as severe depression, poor motivational capacity, or severe language disturbances, particularly of receptive nature or with serious cognitive deficits (defined as equivalent to a mini-mental state exam score (MMSE) of 23 or less), or degenerative brain processes such as Alzheimer's disease
- severe uncontrolled medical problems (e.g., cardiovascular disease, severe rheumatoid arthritis, active joint deformity of arthritic origin, active cancer or renal disease, any kind of end-stage pulmonary or cardiovascular disease, or a deteriorated condition due to age, uncontrolled epilepsy or others), more than moderate to severe microangiopathy, polyneuropathy, diabetes mellitus, or ischemic peripheral disease
- problems with movement of the hands
- receiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants (for the TMS component)
- pregnancy and during lactation
- medical or technical contraindications to MRI procedures or devices producing artifacts that impair MRI signal (e.g., dental braces, pacemakers, implanted medication pumps, cochlear devices, neural stimulators, metal in the cranium, surgical clips, and other metal/magnetic implants, claustrophobia)
Exclusion
Key Trial Info
Start Date :
May 24 2006
Trial Type :
OBSERVATIONAL
End Date :
April 21 2008
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT00331318
Start Date
May 24 2006
End Date
April 21 2008
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892