Status:
COMPLETED
Smoking Cessation Medications: Efficacy, Mechanisms and Algorithms
Lead Sponsor:
University of Wisconsin, Madison
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Nicotine Dependence
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The proposed work will advance the understanding and effectiveness of tobacco dependence treatment and result in more smokers quitting successfully.
Detailed Description
This research study will last for three years. The first year involves a comparison of smoking cessation medications (bupropion, nicotine patch, and nicotine lozenge), including medications used in co...
Eligibility Criteria
Inclusion
- Smoke at least 10 cigarettes per day for the previous 6 months - Expired CO \> 9 ppm - Motivated to quit smoking - Able to read and write English - Willing to complete required study assessments
Exclusion
- Uncontrolled hypertension (systolic \>180mm Hg or diastolic \>110mm Hg) - History of bipolar disorder or psychosis - Myocardial infarction or other serious cardiac problem in the previous 4 weeks - History of diagnosed anorexia and/or bulimia - Diagnosis of Alcohol Dependence in the previous 6 months by participant self-report or drinking 6 or more drinks on six or more days a week - History of seizure and/or serious head injury involving loss of consciousness - Use of contraindicated medications (MAO inhibitors, bupropion, lithium, anticonvulsants, antipsychotics) - Currently pregnant or breast-feeding - Unwilling to use effective contraception during the treatment phase - More than one participant from the same household - Allergic reactions to 3 or more classes of drugs
Key Trial Info
Start Date :
September 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2010
Estimated Enrollment :
1504 Patients enrolled
Trial Details
Trial ID
NCT00332644
Start Date
September 1 2004
End Date
August 1 2010
Last Update
November 30 2011
Active Locations (2)
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1
UW-CTRI Madison Research site
Madison, Wisconsin, United States, 53711
2
UW-CTRI Milwaukee Research site
Milwaukee, Wisconsin, United States, 53233