Status:
COMPLETED
Catecholamine-O-Methyl-Transferase(COMT)-Polymorphism in Cardiac Surgery
Lead Sponsor:
Austin Health
Conditions:
Cardiac Surgery
Eligibility:
All Genders
18+ years
Brief Summary
Although clinical risk factors for postoperative development of vasodilatory shock and acute renal failure have been identified; there is a considerable proportion of patients undergoing cardiac surge...
Detailed Description
Aim of the study To explore if there is an impact of LL COMT genotype on clinical and biological outcome variables in patients undergoing cardiac surgery compared to HH genotype. Background Cardiac...
Eligibility Criteria
Inclusion
- Patients undergoing elective cardiac surgery (in whom CPB is planned) at the Austin Hospital and Warringal Private Hospital.
Exclusion
- Intake of Levodopa
- Intake of COMT inhibitors (e.g. Entacapone, Tolcapone)
- Intake of monoamino oxidase inhibitors type A and B (e.g. Moclobemide, Selegiline, Rasagiline)
- Patients below 18 years of age
- oral steroids
- emergency patients (cardiac symptoms occurred \< 24 hours prior to operation)
- patients receiving IV nitrates/nitroprusside sodium
Key Trial Info
Start Date :
June 1 2006
Trial Type :
OBSERVATIONAL
End Date :
November 1 2006
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT00334009
Start Date
June 1 2006
End Date
November 1 2006
Last Update
March 6 2008
Active Locations (1)
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1
Austin Hospital
Melbourne, Victoria, Australia, 3084