Status:
COMPLETED
Sodium Bicarbonate in Cardiac Surgery
Lead Sponsor:
Austin Health
Conditions:
Cardiac Surgery and Cardiopulmonary Bypass
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Many patients develop kidney failure after cardiac surgery. Although this kidney failure can usually be treated effectively, a longer stay in intensive care is often required. While many patients suff...
Detailed Description
Renal impairment following cardiopulmonary bypass is common. 11.4% to 42% of patients with previously normal renal function show a postoperative rise in serum creatinine. While most of these patients ...
Eligibility Criteria
Inclusion
- Age above 70 years
- Preexisting renal impairment (preoperative serum creatinine level \>120µmol/L
- New York Heart Association class III/IV or Moderate to poor left ventricular dysfunction
- Valve surgery or complex cardiac surgery
- Redo cardiac surgery
- Insulin-dependent diabetes mellitus
Exclusion
- Age \<18 years
- Emergency cardiac surgery
- Planned off-pump cardiac surgery
- Enrolled in conflicting research study
- Known blood-borne infectious disease
- Chronic inflammatory disease on immunosuppression
- Chronic moderate to high dose corticosteroid therapy (\>10mg/d prednisone or equivalent)
- End stage renal disease (serum creatinine \>300µmol/L)
- Thiamine deficiency will be excluded on medical and dietary history.
Key Trial Info
Start Date :
June 1 2006
Trial Type :
INTERVENTIONAL
End Date :
June 1 2006
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00334191
Start Date
June 1 2006
End Date
June 1 2006
Last Update
July 7 2009
Active Locations (1)
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1
Austin Hospital
Melbourne, Victoria, Australia, 3084