Status:
WITHDRAWN
Home Blood Pressure-guided Antihypertensive Intervention for Elderly (HBP-GUIDE) Study
Lead Sponsor:
Kyoto University, Graduate School of Medicine
Collaborating Sponsors:
Kyoto Prefectural University of Medicine
Conditions:
Cardiovascular Disease
Vascular Disease
Eligibility:
All Genders
65-80 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine whether blood pressure control by home blood pressure monitoring exerts beneficial cardioprotective effects rather than by clinic blood pressure monitoring in...
Detailed Description
Home blood pressure (BP) measurement has been reported to be closely correlated with target organ damage and appears to be a prognostic indicator with respect to cardiovascular mortality and cardiovas...
Eligibility Criteria
Inclusion
- Outpatients aged over 65 years and less than 80 years
- Patients with a stable seated systolic blood pressure of ≥ 140 mmHg or diastolic blood pressure of ≥ 90 mmHg at two visits within 8 weeks
- Patients with a stable seated systolic blood pressure of ≥ 135 mmHg or diastolic blood pressure of ≥ 85 mmHg at home (home blood pressure is measured every morning within 1 h of waking, and defined as the mean of 3 days measurement within 8 weeks)
Exclusion
- Patients with secondary hypertension or malignant hypertension
- Patients with a stable seated systolic pressure of ≥ 180 mmHg or diastolic pressure of ≥ 110 mmHg
- Patients with renal dysfunction with a serum creatinine level of ≥ 2 mg/dl
- Patients with liver dysfunction
- Patients with a history of hypersensitivity to angiotensin II receptor blockade
- Patients with a history of myocardial infarction within 6 months prior to enrolment in the study
- Patients who underwent coronary arterioplasty within 6 months prior to enrolment in the study or patients who will undergo coronary arterioplasty within 6 months after entry
- Patients with heart failure
- Patients with a history of cerebrovascular disorder
- Other patients who are judged to be inappropriate for the study by the investigator
Key Trial Info
Start Date :
October 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00334724
Start Date
October 1 2006
End Date
December 1 2008
Last Update
December 29 2015
Active Locations (1)
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1
Division of Internal Medicine, Kyoto Prefectural University of Medicine
Kyoto, Kyoto, Japan, 602-8566