Status:
COMPLETED
Endoscopic Surgery or Radiation Therapy in Treating Patients With Stage 0, Stage I, or Stage II Laryngeal Cancer of the Glottis
Lead Sponsor:
University College London Hospitals
Conditions:
Head and Neck Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
RATIONALE: Endoscopic surgery is a less invasive type of surgery for laryngeal cancer and may have fewer side effects and improve recovery. Radiation therapy uses high-energy x-rays to kill tumor cell...
Detailed Description
OBJECTIVES: * Determine the feasibility of conducting a large phase III randomized study in the future, comparing radiotherapy vs endoscopic excision in patients with stage 0-II laryngeal cancer of t...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Histologically confirmed squamous cell carcinoma of the glottic larynx, including tumors at the anterior commissure
- Stage 0-II (Tis, T1, or T2a)
- No clinical or radiological sign of nodal involvement
- No evidence of distant metastases
- Airway anatomy suitable for endoscopic excision
- PATIENT CHARACTERISTICS:
- Fit to receive radical treatment as either radiotherapy or endoscopic excision
- Life expectancy ≥ 2 years
- No other cancer in the past 10 years except basal cell carcinoma of the skin or adequately treated carcinoma in situ of the uterine cervix
- No vasculitic conditions adversely affecting radiotherapy
- No other co-existing medical condition that would limit life expectancy
- Not pregnant
- PRIOR CONCURRENT THERAPY:
- No concurrent chemotherapy
- No concurrent palliative treatment
Exclusion
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2006
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00334997
Start Date
September 1 2005
End Date
July 1 2006
Last Update
December 19 2013
Active Locations (6)
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1
Southmead Hospital
Bristol, England, United Kingdom, BS10 5NB
2
Aintree University Hospital
Liverpool, England, United Kingdom, L9 7AL
3
Clatterbridge Centre for Oncology
Merseyside, England, United Kingdom, CH63 4JY
4
James Cook University Hospital
Middlesbrough, England, United Kingdom, TS4 3BW