Status:
COMPLETED
Treatment of Uncomplicated Childhood Malaria in Tanzania by Artemether+Lumefantrine - Efficacy and Genotyping
Lead Sponsor:
Karolinska University Hospital
Collaborating Sponsors:
Muhimbili University of Health and Allied Sciences
Conditions:
Malaria
Eligibility:
All Genders
1-10 years
Phase:
PHASE4
Brief Summary
The purpose of this explorative clinical trial is to study parasite population dynamics, diversity and clearance kinetics of Plasmodium falciparum as well as determination of the molecular mechanisms ...
Eligibility Criteria
Inclusion
- Age 1-10 years
- Presence of asexual P. falciparum parasitaemia of 2000-200 000/μL
- No general danger signs or severe malaria present
- Haemoglobin ≥70 g/L
- History of fever within 24 hours OR axillary temperature ≥ 37.5Cº
- No other cause of fever is detectable
- No severe malnutrition
- Guardian/patient has understood the procedures of the study and willing to participate
Exclusion
- Not able to drink or breastfeed
- Vomiting everything
- Recent history of convulsions
- Lethargic or unconscious
- Unable to sit or stand (as appropriate for age)
- History of allergy to test drugs
- History of intake of any drugs other than paracetamol and aspirin within 3 days
- Symptoms/signs of severe malaria
Key Trial Info
Start Date :
June 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2006
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00336375
Start Date
June 1 2006
End Date
July 1 2006
Last Update
November 1 2007
Active Locations (1)
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1
Fukayosi Primary Health Care Center
Fukayosi, Bagamoyo District, Tanzania