Status:
COMPLETED
Renal Transplantation and Inhaled Anesthetic Sevoflurane (SEVOREIN)
Lead Sponsor:
University Hospital, Bordeaux
Collaborating Sponsors:
Ministry of Health, France
Conditions:
End-stage Chronic Renal Disease
Severe Acute Kidney Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
Renal transplantation is characterized by ischemia-reperfusion lesions in allograft. In a previous study, Julier and al. (Anesthesiology 2003) have demonstrated that sevoflurane reduces glomerular les...
Detailed Description
Introduction : Renal transplantation is characterized by ischemia-reperfusion lesions in allografts. Prolonged cold ischemia duration, age of donor (older than 50) or donor cardiac arrest are common ...
Eligibility Criteria
Inclusion
- age \> 18 years
- scheduled to undergo renal allograft transplantation
- transplant : cold ischemia duration \> 20 hours or donor age \> 50 years or donor cardiac arrest
- ASA 2-3
- social security affiliation
- informed consent signed
Exclusion
- halogenated anesthetic agent hypersensibility
- medical history or familial history of malignant hyperthermia
- porphyria
- pregnancy or breast feeding
- hyperimmunized patient
- participation in an immunosuppressive drug trial
Key Trial Info
Start Date :
June 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2010
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00337051
Start Date
June 1 2006
End Date
June 1 2010
Last Update
June 23 2010
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Département d'anesthésie réanimation 1 - Hôpital Pellegrin - CHU de Bordeaux
Bordeaux, France, 33076