Status:
COMPLETED
Observational Study of the Remodelling Process Following Myocardial Infarct
Lead Sponsor:
Helse Stavanger HF
Collaborating Sponsors:
Helse Vest
Amersham Buchler, GmbH & Co KG
Conditions:
Heart Failure
Myocardial Infarct
Eligibility:
All Genders
Brief Summary
This study will assess the relationship between collagen turnover, neurohormonal activation, scarring and left ventricle remodelling in patients 3 years following a myocardial infarction.
Detailed Description
A multinational trial compared losartan vs. captopril in 5477 postinfarction patients with symptoms of heart failure and/or evidence of left ventricular dysfunction. The trial was terminated in 2002 a...
Eligibility Criteria
Inclusion
- Participation in the previous neurohormonal substudy of the OPTIMAAL trial
- Willingness to participate in the present study and ability to understand and sign the written informed consent
Exclusion
- Myocardial infarction within 3 months of visit 1.
- Significant primary valve disease, confirmed by ECHO cardiography,
- Autoimmune disease likely to cause an increase in collagen turnover
- Active cancer disease
- Immunosuppressive treatment,
- Significantly reduced liver function
- Contraindications for performing a cardiac MRI scan (including claustrophobia, implanted ferromagnetic devices or known allergic reactions to Omniscan™).
- Inability to cooperate during the 1 month follow up period.
Key Trial Info
Start Date :
August 1 2003
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2003
Estimated Enrollment :
119 Patients enrolled
Trial Details
Trial ID
NCT00338156
Start Date
August 1 2003
End Date
September 1 2003
Last Update
July 28 2015
Active Locations (1)
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1
Stavanger University Hospital
Stavanger, Norway, NO-4011