Status:
RECRUITING
Molecular Basis of Human Phagocyte Interactions With Bacterial Pathogens
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Host Defense Mechanisms
Eligibility:
All Genders
18-120 years
Brief Summary
Human phagocytic cells such as polymorphonuclear leukocytes (PMNs) are readily mobilized to sites of infection and ingest microorganisms by a process known as phagocytosis. The combined effects of rea...
Detailed Description
Human phagocytic cells such as polymorphonuclear leukocytes (neutrophils or PMNs) are readily mobilized to sites of infection and ingest microorganisms by a process known as phagocytosis. The combined...
Eligibility Criteria
Inclusion
- INCLUSION \& EXCLUSION CRITERIA:
- Volunteers will be selected from a healthy adult population, 18 years of age or older, with no known medical problems and will generally be NIH employees working at Rocky Mountain Laboratories (RML) or within the community of Hamilton, MT.
- No race or gender is excluded from the donor pool and reflects the diversity of the community and that of the employees at RML.
- The specific criteria for eligibility are as follows:
- Subjects must fit the definition of "healthy adults" as assessed by the medical/health screening evaluations, and willing to have blood and/or tissue samples stored for future use.
- Inasmuch as all subjects are RML employees, they will be 18 years of age or older.
- Children are excluded.
- Pregnant women will be identified by verbal history and are not eligible to donate blood for this protocol.
- The study population will be all-inclusive except in certain instances where individuals possess genetic defects that impair phagocyte function (e.g., myeloperoxidase-deficiency) or have altered phagocyte function due to outside influences such as recent bacterial or viral infection.
- Individuals below the normal hematocrit and hemoglobin ranges will be excluded from the protocol.
Exclusion
Key Trial Info
Start Date :
February 12 2001
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00339287
Start Date
February 12 2001
Last Update
December 31 2025
Active Locations (1)
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1
NIAID, Rocky Mountain Laboratories
Hamilton, Montana, United States, 59840