Status:
COMPLETED
Food Intake and Appetite in the Children of Mothers With Diabetes
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Diabetes
Eligibility:
All Genders
7-10 years
Brief Summary
This protocol is for study of the effect of inhibition of parasympathetic outflow on insulin secretion and glucose metabolism. Insulin secretion will be measured during infusions of escalating doses o...
Detailed Description
Children of mothers who had diabetes during pregnancy are at an increased risk of diabetes and obesity in later life, effects partly mediated by the early environment experienced by the offspring of d...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Group 1: Offspring of mothers with diabetes during pregnancy.
- Maternal diagnosis of type 2 diabetes (by WHO criteria after a 75g OGTT or on clinical grounds with at least one random plasma glucose greater than 200mg/dl) before or during the index pregnancy.
- Group 2: Offspring of mothers with diabetes diagnosed following pregnancy.
- Maternal diagnosis of type 2 diabetes (by WHO criteria after a 75g OGTT or on clinical grounds with at least one random plasma glucose greater than 200 mg/dl) after the index pregnancy.
- It is important to also ensure that these mothers did not have any major disturbance in glucose tolerance during the index pregnancy and a record of normal glucose tolerance after the index pregnancy; therefore they will only be included if there are also:
- Adequate records of glucose testing during the index pregnancy and these records are not in keeping with a diagnosis of gestational diabetes (by either WHO criteria if a 75g oral glucose tolerance test has been carried out).
- At least one non-diabetic OGTT after the index pregnancy.
- EXCLUSION CRITERIA:
- History of weight loss for child (greater than 2kg over last 6 months).
- Presence of other major illnesses which might interfere with appetite or food intake in mother or child.
- Child not living with mother.
Exclusion
Key Trial Info
Start Date :
January 12 2000
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 24 2011
Estimated Enrollment :
240 Patients enrolled
Trial Details
Trial ID
NCT00339313
Start Date
January 12 2000
End Date
June 24 2011
Last Update
July 2 2017
Active Locations (1)
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1
NIDDK, Phoenix
Phoenix, Arizona, United States, 85014