Status:
COMPLETED
Exploratory Data Analysis for Disease Pedigrees and Cancer Genetics
Lead Sponsor:
National Human Genome Research Institute (NHGRI)
Conditions:
Data Analysis
Cancer Genetics
Eligibility:
All Genders
Brief Summary
The researchers have developed and distributed several software packages for pedigree analysis (FAST, CASPAR, PedHunter, IIC) and cancer genetics (oncotree, METREX). Users who need assistance with the...
Detailed Description
We have developed software packages for pedigree analysis (FAST, CASPAR, PedHunter, IIC) and cancer genetics (oncotrees, METREX). The purpose of this protocol is to allow us to work on software proble...
Eligibility Criteria
Inclusion
- INCLUSION/EXCLUSION CRITERIA:
- User Requests:
- When receiving data sets for problem reports and/or new feature requests, all data sets would be accepted. We would not consider how the data were collected. The reasons for this are: the medical aspects of the data set are irrelevant to the reason we receiving the data; we cannot respond promptly to problem reports, if we have to get details on how the data were collected; the data are never used by us for any research into the traits being studies by the researchers who collected data.
- Collaborations:
- For collaborative studies, we would request details of how the data were collected, including evidence of approval by a local ethics board. We would submit to the NHGRI IRB an amendment describing the new collaboration. That amendment would necessarily include a formal indication that the collaborating research group has permission to collect and analyze the human data that they present to us (in coded and summarized format). For collaborators in the United States that permission would consist of an IRB-approved protocol or exemption from the collaborator's institution. For collaborators outside the United States the permission would be one of the types of agreements currently supported by the NIH Office of Human Subjects Research.
- If we do not see evidence of appropriate permission to collect the data or the IRB turns down our proposed amendment, then we would exclude ourselves from participating in the proposed collaboration.
- There are two other circumstances under which we have also excluded collaborating on analysis of data sets in the past and may do so in the future. One circumstance was where we did not feel that the proposed data set could possibly give sufficient statistical power to detect anything interesting. The other circumstance was where we had an existing collaboration with one research group, and a competing group asked us to collaborate also.
Exclusion
Key Trial Info
Start Date :
March 19 2002
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 9 2017
Estimated Enrollment :
13385 Patients enrolled
Trial Details
Trial ID
NCT00339508
Start Date
March 19 2002
End Date
May 9 2017
Last Update
April 5 2018
Active Locations (1)
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1
National Human Genome Research Institute (NHGRI), 9000 Rockville Pike
Bethesda, Maryland, United States, 20892