Status:
COMPLETED
Genetic Epidemiology of Lung Cancer and Smoking
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Lung Cancer
Eligibility:
All Genders
35-79 years
Brief Summary
We will conduct an interdisciplinary case-control/sib-pair study of lung cancer designed to explore the genetic determinants both of lung cancer and of smoking. The study includes biospecimen collecti...
Detailed Description
This is an interdisciplinary multicenter case-control study of lung cancer situated in Milan Italy, designed to explore the genetic determinants both of lung cancer and of smoking. We enrolled newly d...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA - CASE GROUP:
- The case group will consist of 2,000 newly incident lung cancer cases, male and female, 35 to 79 years old, with verified lung cancer, collected before or after surgery and prior to chemotherapy or radiation therapy.
- All histologic types and all stages of lung cancer will be eligible.
- Cases will be consecutively collected in the departments of thoracic surgery, general surgery, general medicine, and oncology.
- The pool of cases will be residents of Lombardy derived from 5 cities (Milan, Brescia, Varese, Monza, and Pavia) and the surrounding residential villages served by 14 hospitals, that encompass all five medical schools in the region.
- Enrolled cases will have no history of other cancers, except for basal cell carcinoma of the skin or in situ cervical carcinoma.
- Subjects in intensive care units, or with cardiac, hepatic, renal, or CNS failure, or with uncompensated schizophrenia, psychosis, or inability to speak, will not be enrolled.
- All subjects will sign an informed consent.
- INCLUSION CRITERIA - CONTROL GROUP:
- The control group will consist of 2,000 gender-, age-, and county-matched controls with no history of cancer.
- We will choose a population-based or hospital-based control group depending on the result of a pilot study.
Exclusion
Key Trial Info
Start Date :
June 28 2001
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 26 2020
Estimated Enrollment :
4429 Patients enrolled
Trial Details
Trial ID
NCT00340340
Start Date
June 28 2001
End Date
June 26 2020
Last Update
June 30 2020
Active Locations (18)
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1
Ospedale Fatebenefratelli Sant'Orsola
Brescia, Italy
2
Spedali Civili
Brescia, Italy
3
Azienda Ospedaliera San Paolo
Milan, Italy
4
Euromedia Marketing Service
Milan, Italy