Status:
COMPLETED
Effect of Genetic Differences on Levels of Water Disinfection Byproducts in Blood After Showering
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Normal Physiology
Eligibility:
All Genders
18-90 years
Brief Summary
This study will examine whether genetic differences among individuals affect blood levels of certain chemicals called DBPs after showering. Chemicals such as chlorine and ozone are used to kill germs ...
Detailed Description
Disinfection byproducts in drinking water (DBP) are inadvertently created when chlorine interacts with organic compounds in the untreated water. DBP have been implicated in elevated risk of several ty...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- The study population will be comprised of non-smoking males and females in the age range 18-45 years. The age range was selected to limit variability in activity of important enzyme systems.
- EXCLUSIONS CRITERIA:
- Persons with lung conditions will be excluded because inhalation is a major route of exposure for trihalomethanes.
- Liver conditions will be excluded because of the potential risks possibly associated with chlorzoxazone administration.
- Pregnant and lactating women will be excluded from participation in the study, for multiple reasons, the major one being possible (but unknown) adverse health risks from chlorzoxazone exposure.
- In addition, we will exclude persons with chronic conditions such as diabetes who chronically use medication, such as Orinase or others. These persons will be excluded due to unknown effects of such disease on the enzyme systems under investigation and to avoid any possible adverse effects of the study, including chlorzoxazone administration.
Exclusion
Key Trial Info
Start Date :
June 23 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 4 2021
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00340535
Start Date
June 23 2004
End Date
March 4 2021
Last Update
March 5 2021
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15261