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Status:

COMPLETED

Genetic Analysis of Hereditary Non-Syndromic Oral Clefts

Lead Sponsor:

National Human Genome Research Institute (NHGRI)

Conditions:

Hereditary Oral Clefts

Eligibility:

All Genders

Brief Summary

In a collaborative effort with the IBN AL-NAFEES Hospital (Damascus, Syrian Arab Republic), individuals from multiplex families determined to have hereditary oral clefts will be studied. The purpose o...

Detailed Description

In a collaborative effort with the IBN AL-NAFEES Hospital (Damascus, Syrian Arab Republic), individuals from multiplex families determined to have hereditary oral clefts will be studied. Healthy Syria...

Eligibility Criteria

Inclusion

  • INCLUSION CRITERIA:
  • Enrollment in this study will be limited to individuals with non-syndromic unilateral or bilateral cleft lip with or without cleft palate and their unaffected relatives, from families which meet the following criteria:
  • A cluster of 2 or more affected first degree relatives, such as a parent and two offspring or 2 siblings, or
  • The occurrence of oral clefts in each of 2 generations in either the proband's paternal or maternal lineages.
  • The occurrence of oral clefts in 2 or more cousins (up to second cousins)
  • The subject population is comprised of probands and their families previously examined at the IBN-AL NAFEES Hospital or at other hospitals and clinics in the Syrian Arab Republic as well
  • as healthy controls from the same population. Consent documents are in Arabic language for non-English-speaking subjects
  • EXCLUSION CRITERIA:
  • Individuals unable to provide consent, except for cases who are children and mentally impaired persons with consenting parents or guardians.

Exclusion

    Key Trial Info

    Start Date :

    August 31 1997

    Trial Type :

    OBSERVATIONAL

    Allocation :

    ACTUAL

    End Date :

    March 12 2020

    Estimated Enrollment :

    690 Patients enrolled

    Trial Details

    Trial ID

    NCT00340626

    Start Date

    August 31 1997

    End Date

    March 12 2020

    Last Update

    March 13 2020

    Active Locations (1)

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    Page 1 of 1 (1 locations)

    1

    IBN Al Nafees Hospital

    Damascus, Syria