Status:
COMPLETED
Doxycycline to Treat Mansonella Perstans Infection in Patients With and Without Lymphatic Filariasis
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Mansonella Perstans Infection
Mp Microfilaremia
Eligibility:
All Genders
14-65 years
Phase:
PHASE2
Brief Summary
This study will examine: 1) the safety and effectiveness of the drug doxycycline in reducing the number of Mansonella perstans (Mp) worms in the blood of infected patients, and 2) the effects of doxyc...
Detailed Description
Mansonella perstans (Mp) infection is common in areas of Africa that are endemic for Wuchereria bancrofti (Wb), a causative agent of lymphatic filariasis. The clinical and immunologic contributions of...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA - SCREENING:
- Age 14 to 65.
- Both genders.
- Not pregnant or breastfeeding by history.
- EXCLUSION CRITERIA - SCREENING:
- Non-volunteers.
- Age less than 14 or greater than 65.
- Pregnant or breastfeeding by history.
- INCLUSION CRITERIA - TREATMENT:
- Age 14 to 65 years.
- Men and non-pregnant or breastfeeding women.
- EXCLUSION CRITERIA - TREATMENT:
- Non-volunteers.
- Age less than 14 or greater than 65.
- Pregnancy or breast-feeding.
- Hgb less than or equal to 10 g/dl.
- Cr greater than 1.4/100 ml.
- ALT greater than 45 U or bilirubin greater than 1.5.
- Weight less than 40 kg.
- Heavy alcohol use (more than 1 beer or other alcohol-containing drink/day).
- Temperature greater than 37.5C or other serious medical illnesses.
- History of allergy to doxycycline or other tetracyclines.
- History of HIV infection or other immunocompromised state.
Exclusion
Key Trial Info
Start Date :
December 6 2004
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
1500 Patients enrolled
Trial Details
Trial ID
NCT00340691
Start Date
December 6 2004
Last Update
July 2 2017
Active Locations (1)
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1
National Institute of Allergy and Infectious Diseases (NIAID), 9000 Rockville Pi
Bethesda, Maryland, United States, 20892