Status:
COMPLETED
Molecular Epidemiology of Dioxin-Related Illness in Seveso
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
2,3,7,8-Tetrachlorodibenzo-Para-Dioxin (TCDD) Exposure
Eligibility:
All Genders
18-100 years
Brief Summary
In 1976 an accidental explosion in a chemical plant 16 miles north of Milan resulted in contamination of the local population with 2, 3, 7, 8-terachlorodibenzo-para-dioxin (TCDD). There is evidence th...
Detailed Description
In 1976 an accidental explosion in a chemical plant 16 miles north of Milan resulted in contamination of the local population with 2, 3, 7, 8-tetrachlorodibenzo-para-dioxin (TCDD). There is evidence t...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Subjects exposed to TCDD in the region of Lombardy, Italy.
- EXCLUSION CRITERIA:
- severe medical illness: liver (cirrhosis \[based on medical history\], chronic or acute hepatitis \[based on transaminase elevation, SGOT greater than 200 IU or SGPT greater than 200 IU\]), kidney (hemo- or peritoneal dialysis dependent), cardiac (myocardial infarct in the last 6 months), AIDS (or known HIV positive), major psychiatric illness (decompensated schizophrenia);
- IV drug abuse;
- individuals receiving a few specific medications known to interfere with specific assays (i.e., phenobarbitol), other medication use will be recorded;
- non-Italian origin;
- Any condition which precludes obtaining informed consent.
Exclusion
Key Trial Info
Start Date :
December 12 1994
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 16 2020
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT00340873
Start Date
December 12 1994
End Date
April 16 2020
Last Update
April 20 2020
Active Locations (1)
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1
University of Milan
Milan, Italy