Status:
COMPLETED
Exercise Training in Older Diabetic Women
Lead Sponsor:
University of San Francisco
Collaborating Sponsors:
University of California, San Francisco
Conditions:
Cardiovascular Diseases
Diabetes Mellitus, Type 2
Eligibility:
FEMALE
45-75 years
Phase:
PHASE1
Brief Summary
Type 2 diabetics (non-insulin-dependent) are more than five times as likely to suffer an initial myocardial infarction (MI; heart attack) compared to nondiabetics.Female diabetics in particular, have ...
Detailed Description
* Recruitment: Participants who have signed up for the research recruitment mailing list at the UCSF/Mt. Zion Osteoporosis Center will be mailed a CHR approved recruitment letter that briefly describe...
Eligibility Criteria
Inclusion
- Female 45-75 yrs old
- Type 2 diabetic for \> 6 months
- "Reasonable" control of diabetes
- blood glucose within 100-250 mg/dl prior to exercise
- absence of hypoglycemic symptoms
- diabetes control verified by physician
- cleared by physician to begin exercise program
- Postmenopausal \> 6 months
- Sedentary
- Ability and willingness of patient to give written, informed consent
- Able and willing to participate in an exercise intervention
Exclusion
- Diabetes not in control
- unable to maintain blood glucose within 100-250 mg/dl
- development of urinary ketone bodies (ketosis)
- symptoms of hypoglycemia before, during, and post-exercise
- no physician's approval to participate
- Male
- Female \<45 or \>75 yr
- \> 300 lb (weight limit for DXA table)
- On insulin
- Contraindications to Exercise Testing (ACSM, 2000)
- Ischemia
- Recent myocardial infarction
- Unstable angina
- Uncontrolled cardiac arrhythmias
- Severe aortic stenosis
- Uncontrolled heart failure
- Acute pulmonary embolus
- Acute myocarditis or pericarditis
- Dissecting aneurysm
- Acute infections
- Electrolyte abnormalities
- Severe hypertension (SBP \> 200 mm Hg, DBP \> 110 mm Hg at rest)
- Tachyarrhythmias or bradyarrhythmias
- Hypertrophic cardiomyopathy
- Neuromuscular, musculoskeletal, or rheumatoid disorders that are exacerbated by exercise
- Not able to complete exercise testing (i.e must be ambulatory and without orthopedic limitations which would preclude maximal effort exercise)
Key Trial Info
Start Date :
June 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2007
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT00341614
Start Date
June 1 2006
End Date
May 1 2007
Last Update
August 16 2007
Active Locations (1)
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1
University of California, San Francisco
San Francisco, California, United States, 94143