Status:
ENROLLING_BY_INVITATION
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan
Lead Sponsor:
National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions:
Hearing Disorder
Eligibility:
All Genders
2+ years
Brief Summary
Objective: One objective of this study is to genetically map and identify mutated genes for human hereditary hearing loss. A second objective is to study the function of these genes in the auditory sy...
Detailed Description
Objective: One objective of this study is to genetically map and identify mutated genes for human hereditary hearing loss. A second objective is to study the function of these genes in the auditory sy...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Affected and unaffected members of families segregating deafness caused by genetic etiology.
- Adults must be able to provide informed consent.
- Adults must be able to provide informed consent for children who are at least two years of age
- All communities, ethnicities, and races as found in Pakistan.
- EXCLUSION CRITERIA:
- Persons with non-genetic forms of hearing loss likely due to acquired causes such as an infection, head or noise trauma, or exposure to an ototoxic drug will not be included in this protocol
- Syndromic forms of inherited deafness are excluded if the gene for the disorder is known and there is no reason to believe the disorder is genetically heterogeneous.
- Subjects cannot provide informed consent or have a parent/guardian that cannot provide consent.
- Children under the age of two years will not be included in this study because an objective audiological examination such as an ABR analysis may require sedation, which is presently not feasible in Pakistan.
Exclusion
Key Trial Info
Start Date :
March 16 2000
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
24000 Patients enrolled
Trial Details
Trial ID
NCT00341874
Start Date
March 16 2000
Last Update
January 5 2026
Active Locations (1)
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1
University of Punjab
Lahore, Pakistan